Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.
نویسندگان
چکیده
Ceftobiprole exhibited tight binding to PBP2a in methicillin-resistant Staphylococcus aureus, PBP2x in penicillin-resistant Streptococcus pneumoniae, and PBP3 and other essential penicillin-binding proteins in methicillin-susceptible S. aureus, Escherichia coli, and Pseudomonas aeruginosa. Ceftobiprole also bound well to PBP2 in the latter organisms, contributing to the broad-spectrum antibacterial activity against gram-negative and gram-positive bacteria.
منابع مشابه
Binding of Ceftobiprole and Comparators to the Penicillin - Binding Proteins of Escherichia coli , 1 Pseudomonas aeruginosa , Staphylococcus aureus and Streptococcus pneumoniae
2 Basilea Pharmaceutica AG, Grenzacherstrasse 487, PO Box, CH-4005 Basel, Switzerland 8 9 Running title: Affinity of ceftobiprole to bacterial PBPs 10 11 Please send all correspondence to: 12 Todd Davies 13 Johnson & Johnson Pharmaceutical Research & Development, L.L.C 14 Room B225 15 1000 Route 202 16 Raritan, NJ 08869 17 Phone: (908) 707-3465 18 Fax: (908) 707-3501 19 Email: [email protected]...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 7 شماره
صفحات -
تاریخ انتشار 2007